G‐protein coupled receptor kinases as modulators of G‐protein signalling
نویسندگان
چکیده
منابع مشابه
G protein-coupled receptor kinases.
G protein-coupled receptor kinases (GRKs) constitute a family of six mammalian serine/threonine protein kinases that phosphorylate agonist-bound, or activated, G protein-coupled receptors (GPCRs) as their primary substrates. GRK-mediated receptor phosphorylation rapidly initiates profound impairment of receptor signaling, or desensitization. This review focuses on the regulation of GRK activity...
متن کاملRelationship Between RKIP Protein Expression and Clinical Staging in Thyroid Carcinoma
Raf-1 Kinase Inhibitory Protein (RKIP) belongs to a new class modulators of signalling cascades involved in maintaining of biological balance in many living organisms. RKIP targets and inhibits different kinases (Mitogen Activated Protein (MAP) kinase, Gprotein coupled receptor (GPCR) kinase and nuclear factor kappa B (NFB) signaling pathways), and its loss is associated with progression of man...
متن کاملToxicology G Protein - Coupled Receptor Kinases
The importance of G protein-coupled receptor (GPCR) kinases (GRKs) as regulators of GPCR signaling has been widely recognized. In humans, GRKs constitute a family of seven protein kinases involved in the phosphorylation and desensitization of agonist-activated GPCRs in many physiological processes. The GPCR desensitization process is initiated by GRKs, but involves several subsequent steps incl...
متن کاملMolecular basis for activation of G protein-coupled receptor kinases.
G protein-coupled receptor (GPCR) kinases (GRKs) selectively recognize and are allosterically regulated by activated GPCRs, but the molecular basis for this interaction is not understood. Herein, we report crystal structures of GRK6 in which regions known to be critical for receptor phosphorylation have coalesced to stabilize the kinase domain in a closed state and to form a likely receptor doc...
متن کاملThe Role of G Protein-coupled Receptor Kinases in Cancer
G protein-coupled receptors (GPCRs) are the largest family of plasma membrane receptors. Emerging evidence demonstrates that signaling through GPCRs affects numerous aspects of cancer biology such as vascular remolding, invasion, and migration. Therefore, development of GPCR-targeted drugs could provide a new therapeutic strategy to treating a variety of cancers. G protein-coupled receptor kina...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1999
ISSN: 0022-3751,1469-7793
DOI: 10.1111/j.1469-7793.1999.0005z.x